I believe UP1USA ships from the UK so they will be obliged to add customs data for EU users from now on, which will lead to local taxes being applied on import as though they shipped from the USA. That will make the UK import companies a lot worse for EU users who will end up paying more than if they import from the USA directly themselves now.
For UK users, reshipping through Europe or relying on sneaking under the Customs VAT threshold no longer applies, so the only way to get stuff imported without any extra charges is to use a UK-based company (like Otaku/UP1) who will import on your behalf then ship within the UK. Stores based outside the UK are supposed to charge taxes (and any associated fees) during checkout now, though it may take some of them a while to figure things out and some might block all UK orders outright until they have a system in place. Some might block UK orders permanently because registering for UK VAT to serve a tiny number of customers in the UK doesn't always make sense.
In a practical sense it probably means less choice and higher prices for importing across the board, but the benefit is that when it works you will get taxes displayed up front (like Amazon) instead of being shocked by a Royal Mail ransom note on delivery. Meanwhile, folks in Europe are going to be getting their local equivalent of a Customs ransom note whenever they buy from the UK, which means that UK distributors are going to be making fewer sales to European fans. There will probably be belt tightening on every side of the situation.
R