Yes, yes! You've nailed it exactly there. Glad to know it's not a technical fault.It can be pretty bad in some scenes though, like the classroom one @~6 minutes in. To me that sounds more like what I'd expect from a questionable quality Youtube video. Don't really know how to explain it either to be honest. Maybe an echo/reverb effect?
By the way, I took at look at the DVD. The audio is, of course, exactly the same. Has anyone seen the video quality on it, though?
Edit: Also, I was wondering whether Anime Limited's DVD version of Space Dandy was free from the problem with missing opening/ending subs that the BD has. Can anyone confirm?