Anyone who says that Resident Evil 5 is racist are uninformed or racists themselves, plain as that. Some people may look at a glimpse of a trailer, a white man kills black people. However, these people do not see the underlying plot of the game which is that those black people were contaminated with an apparently uncurable virus. Killing those people was only to help save this fictional town/village/country the game is set in. There was a huge row on a website called blacklooks.org, because the author of the blog decided that Resident Evil 5 was racist. She got hundreds of comments on that post, the majority stating she was wrong.
So basically anyone who is against Resident Evil 5 being set in a country with black natives, and said natives turn into zombies that need to be killed to save the country, and is well informed of the facts, is racist in my opinion at least.